Production of interleukin-13 is influenced by the interleukin-4 -34TT and -590TT genotype in patients with aggressive periodontitis.
Identifieur interne : 000310 ( Main/Exploration ); précédent : 000309; suivant : 000311Production of interleukin-13 is influenced by the interleukin-4 -34TT and -590TT genotype in patients with aggressive periodontitis.
Auteurs : J R Gonzales [Allemagne] ; S. Gröger ; G. Haley ; R-H Bödeker ; J. MeyleSource :
- Scandinavian journal of immunology [ 1365-3083 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Femelle (MeSH), Génotype (MeSH), Humains (MeSH), Interféron gamma (biosynthèse), Interféron gamma (immunologie), Interleukine-13 (biosynthèse), Interleukine-13 (immunologie), Interleukine-2 (biosynthèse), Interleukine-2 (immunologie), Interleukine-4 (génétique), Interleukine-4 (immunologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD4+ (métabolisme), Mâle (MeSH), Parodontite chronique (anatomopathologie), Parodontite chronique (génétique), Parodontite chronique (immunologie), Régulation de l'expression des gènes (MeSH).
- MESH :
- anatomopathologie : Parodontite chronique.
- biosynthèse : Interféron gamma, Interleukine-13, Interleukine-2.
- génétique : Interleukine-4, Parodontite chronique.
- immunologie : Interféron gamma, Interleukine-13, Interleukine-2, Interleukine-4, Lymphocytes T CD4+, Parodontite chronique.
- métabolisme : Lymphocytes T CD4+.
- Adulte, Femelle, Génotype, Humains, Mâle, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Adult (MeSH), CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (metabolism), Chronic Periodontitis (genetics), Chronic Periodontitis (immunology), Chronic Periodontitis (pathology), Female (MeSH), Gene Expression Regulation (MeSH), Genotype (MeSH), Humans (MeSH), Interferon-gamma (biosynthesis), Interferon-gamma (immunology), Interleukin-13 (biosynthesis), Interleukin-13 (immunology), Interleukin-2 (biosynthesis), Interleukin-2 (immunology), Interleukin-4 (genetics), Interleukin-4 (immunology), Male (MeSH).
- MESH :
- chemical , biosynthesis : Interferon-gamma, Interleukin-13, Interleukin-2.
- genetics : Chronic Periodontitis, Interleukin-4.
- immunology : CD4-Positive T-Lymphocytes, Chronic Periodontitis, Interferon-gamma, Interleukin-13, Interleukin-2, Interleukin-4.
- metabolism : CD4-Positive T-Lymphocytes.
- pathology : Chronic Periodontitis.
- Adult, Female, Gene Expression Regulation, Genotype, Humans, Male.
Abstract
Aggressive periodontitis (AgP) is a specific form of periodontal disease, with rapid destruction of the tissues supporting the teeth in otherwise young healthy individuals. We recently showed a higher frequency of the interleukin-4 (IL-4) -34TT and -590TT genotype in AgP patients compared to controls (P<0.05). Herein, we demonstrated that this specific IL-4 genotype exerts its function by increasing expression of IL-4 and STAT6, and producing higher concentrations of IL-4 in activated CD4+ cells of patients with AgP. In the present study, we investigated the effects of the IL-4-specific genotype on IL-13, IL-2 and IFN-γ expression and production in activated CD4+ cells of patients with AgP and healthy controls. Results revealed higher IFN-γ and IL-2 expression and significantly increased IL-13 production in the cells of the patients who were homozygous for the -34T and -590T alleles in comparison with the patients who were homozygous for the -34C and -590C alleles (P<0.05). Results of controls with the -34C and -590C alleles were similar to those of AgP with the same genotype. To our knowledge, the present study is the first to show an effect of the -34TT and -590TT genotype on IL-13 production. There is an increased production of IL-13 by the T cells of aggressive periodontitis patients with the IL-4 genotype.
DOI: 10.1111/j.1365-3083.2010.02482.x
PubMed: 21198753
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Gröger</name></author><author><name sortKey="Haley, G" sort="Haley, G" uniqKey="Haley G" first="G" last="Haley">G. Haley</name></author><author><name sortKey="Bodeker, R H" sort="Bodeker, R H" uniqKey="Bodeker R" first="R-H" last="Bödeker">R-H Bödeker</name></author><author><name sortKey="Meyle, J" sort="Meyle, J" uniqKey="Meyle J" first="J" last="Meyle">J. Meyle</name></author></analytic><series><title level="j">Scandinavian journal of immunology</title><idno type="eISSN">1365-3083</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD4-Positive T-Lymphocytes (metabolism)</term><term>Chronic Periodontitis (genetics)</term><term>Chronic Periodontitis (immunology)</term><term>Chronic Periodontitis (pathology)</term><term>Female (MeSH)</term><term>Gene Expression Regulation (MeSH)</term><term>Genotype (MeSH)</term><term>Humans (MeSH)</term><term>Interferon-gamma (biosynthesis)</term><term>Interferon-gamma (immunology)</term><term>Interleukin-13 (biosynthesis)</term><term>Interleukin-13 (immunology)</term><term>Interleukin-2 (biosynthesis)</term><term>Interleukin-2 (immunology)</term><term>Interleukin-4 (genetics)</term><term>Interleukin-4 (immunology)</term><term>Male (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Femelle (MeSH)</term><term>Génotype (MeSH)</term><term>Humains (MeSH)</term><term>Interféron gamma (biosynthèse)</term><term>Interféron gamma (immunologie)</term><term>Interleukine-13 (biosynthèse)</term><term>Interleukine-13 (immunologie)</term><term>Interleukine-2 (biosynthèse)</term><term>Interleukine-2 (immunologie)</term><term>Interleukine-4 (génétique)</term><term>Interleukine-4 (immunologie)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD4+ (métabolisme)</term><term>Mâle (MeSH)</term><term>Parodontite chronique (anatomopathologie)</term><term>Parodontite chronique (génétique)</term><term>Parodontite chronique (immunologie)</term><term>Régulation de l'expression des gènes (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term><term>Interleukin-13</term><term>Interleukin-2</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Parodontite chronique</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron gamma</term><term>Interleukine-13</term><term>Interleukine-2</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chronic Periodontitis</term><term>Interleukin-4</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Interleukine-4</term><term>Parodontite chronique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interféron gamma</term><term>Interleukine-13</term><term>Interleukine-2</term><term>Interleukine-4</term><term>Lymphocytes T CD4+</term><term>Parodontite chronique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Chronic Periodontitis</term><term>Interferon-gamma</term><term>Interleukin-13</term><term>Interleukin-2</term><term>Interleukin-4</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T CD4+</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Chronic Periodontitis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Gene Expression Regulation</term><term>Genotype</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Régulation de l'expression des gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aggressive periodontitis (AgP) is a specific form of periodontal disease, with rapid destruction of the tissues supporting the teeth in otherwise young healthy individuals. We recently showed a higher frequency of the interleukin-4 (IL-4) -34TT and -590TT genotype in AgP patients compared to controls (P<0.05). Herein, we demonstrated that this specific IL-4 genotype exerts its function by increasing expression of IL-4 and STAT6, and producing higher concentrations of IL-4 in activated CD4+ cells of patients with AgP. In the present study, we investigated the effects of the IL-4-specific genotype on IL-13, IL-2 and IFN-γ expression and production in activated CD4+ cells of patients with AgP and healthy controls. Results revealed higher IFN-γ and IL-2 expression and significantly increased IL-13 production in the cells of the patients who were homozygous for the -34T and -590T alleles in comparison with the patients who were homozygous for the -34C and -590C alleles (P<0.05). Results of controls with the -34C and -590C alleles were similar to those of AgP with the same genotype. To our knowledge, the present study is the first to show an effect of the -34TT and -590TT genotype on IL-13 production. There is an increased production of IL-13 by the T cells of aggressive periodontitis patients with the IL-4 genotype.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21198753</PMID><DateCompleted><Year>2011</Year><Month>01</Month><Day>31</Day></DateCompleted><DateRevised><Year>2011</Year><Month>01</Month><Day>04</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1365-3083</ISSN><JournalIssue CitedMedium="Internet"><Volume>73</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Scandinavian journal of immunology</Title><ISOAbbreviation>Scand J Immunol</ISOAbbreviation></Journal><ArticleTitle>Production of interleukin-13 is influenced by the interleukin-4 -34TT and -590TT genotype in patients with aggressive periodontitis.</ArticleTitle><Pagination><MedlinePgn>128-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-3083.2010.02482.x</ELocationID><Abstract><AbstractText>Aggressive periodontitis (AgP) is a specific form of periodontal disease, with rapid destruction of the tissues supporting the teeth in otherwise young healthy individuals. We recently showed a higher frequency of the interleukin-4 (IL-4) -34TT and -590TT genotype in AgP patients compared to controls (P<0.05). Herein, we demonstrated that this specific IL-4 genotype exerts its function by increasing expression of IL-4 and STAT6, and producing higher concentrations of IL-4 in activated CD4+ cells of patients with AgP. In the present study, we investigated the effects of the IL-4-specific genotype on IL-13, IL-2 and IFN-γ expression and production in activated CD4+ cells of patients with AgP and healthy controls. Results revealed higher IFN-γ and IL-2 expression and significantly increased IL-13 production in the cells of the patients who were homozygous for the -34T and -590T alleles in comparison with the patients who were homozygous for the -34C and -590C alleles (P<0.05). Results of controls with the -34C and -590C alleles were similar to those of AgP with the same genotype. To our knowledge, the present study is the first to show an effect of the -34TT and -590TT genotype on IL-13 production. There is an increased production of IL-13 by the T cells of aggressive periodontitis patients with the IL-4 genotype.</AbstractText><CopyrightInformation>© 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gonzales</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Periodontology, Justus-Liebig-University, Giessen, Germany. jose.gonzales@dentist.med.uni-giessen.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gröger</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Haley</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Bödeker</LastName><ForeName>R-H</ForeName><Initials>RH</Initials></Author><Author ValidYN="Y"><LastName>Meyle</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Immunol</MedlineTA><NlmUniqueID>0323767</NlmUniqueID><ISSNLinking>0300-9475</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018793">Interleukin-13</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007376">Interleukin-2</NameOfSubstance></Chemical><Chemical><RegistryNumber>207137-56-2</RegistryNumber><NameOfSubstance UI="D015847">Interleukin-4</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055113" MajorTopicYN="N">Chronic Periodontitis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018793" MajorTopicYN="N">Interleukin-13</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007376" MajorTopicYN="N">Interleukin-2</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015847" MajorTopicYN="N">Interleukin-4</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21198753</ArticleId><ArticleId IdType="doi">10.1111/j.1365-3083.2010.02482.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bodeker, R H" sort="Bodeker, R H" uniqKey="Bodeker R" first="R-H" last="Bödeker">R-H Bödeker</name><name sortKey="Groger, S" sort="Groger, S" uniqKey="Groger S" first="S" last="Gröger">S. Gröger</name><name sortKey="Haley, G" sort="Haley, G" uniqKey="Haley G" first="G" last="Haley">G. Haley</name><name sortKey="Meyle, J" sort="Meyle, J" uniqKey="Meyle J" first="J" last="Meyle">J. Meyle</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Gonzales, J R" sort="Gonzales, J R" uniqKey="Gonzales J" first="J R" last="Gonzales">J R Gonzales</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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